Title : Designing calcium-sensitizing mutations in the regulatory domain of cardiac troponin C.

Pub. Date : 2004 Aug 20

PMID : 15205455






1 Functional Relationships(s)
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1 To sensitize the N-domain of cardiac troponin C(F27W) to calcium, we individually substituted the hydrophobic residues Phe(20), Val(44), Met(45), Leu(48), and Met(81) with polar Gln. Leucine troponin C1, slow skeletal and cardiac type Homo sapiens