Title : Comparison of molecular dynamics averaged structures for complexes of normal and oncogenic ras-p21 with SOS nucleotide exchange protein, containing computed conformations for three crystallographically undefined domains, suggests a potential role of these domains in ras signaling.

Pub. Date : 2004 Apr

PMID : 15200053






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 ras-p21 protein binds to the son-of-sevenless (SOS) guanine nucleotide-exchange promoter that allows it to exchange GDP for GTP. Guanosine Triphosphate H3 histone pseudogene 16 Homo sapiens
2 Overall, our current results suggest that SOS interactions with oncogenic ras-p21 may enhance ras-p21 mitogenic signaling through prolonging its activation by maintaining its binding to GTP and by allowing its effector domains to interact with intracellular targets. Guanosine Triphosphate H3 histone pseudogene 16 Homo sapiens
3 Overall, our current results suggest that SOS interactions with oncogenic ras-p21 may enhance ras-p21 mitogenic signaling through prolonging its activation by maintaining its binding to GTP and by allowing its effector domains to interact with intracellular targets. Guanosine Triphosphate H3 histone pseudogene 16 Homo sapiens