Pub. Date : 2004 Jun
PMID : 15198897
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To evaluate its role in airway remodeling in asthma, we observed the effects of an angiotensin II type 1 receptor antagonist (valsartan) on the expression of collagen III, collagen V, and transforming growth factor beta1 (TGF-beta1) mRNA and protein in the airway walls of sensitized rats. | Valsartan | transforming growth factor, beta 1 | Rattus norvegicus |
| 2 | To evaluate its role in airway remodeling in asthma, we observed the effects of an angiotensin II type 1 receptor antagonist (valsartan) on the expression of collagen III, collagen V, and transforming growth factor beta1 (TGF-beta1) mRNA and protein in the airway walls of sensitized rats. | Valsartan | transforming growth factor, beta 1 | Rattus norvegicus |
| 3 | The expression of TGF-beta1 mRNA and protein in the airways was significantly higher in rats from the sensitized group (20.49% +/- 3.46%, 29.73% +/- 3.25%) and from valsartan groups 1, 2, and 3 (16.47% +/- 1.94%, 19.41% +/- 1.87%; 14.38% +/- 1.58%, 18.29% +/- 1.43%; 12.96% +/- 1.73%, 18.63% +/- 1.11%, respectively) than that from the control group (7.84% +/- 1.61%, 5.63% +/- 1.07%, P < 0.05). | Valsartan | transforming growth factor, beta 1 | Rattus norvegicus |
| 4 | TGF-beta1 mRNA and protein levels were significantly lower in valsartan groups 1, 2, and 3 than that in the sensitized group (P < 0.05). | Valsartan | transforming growth factor, beta 1 | Rattus norvegicus |
| 5 | CONCLUSIONS: Angiotensin II receptor antagonist valsartan can suppress synthesis of collagen III and collagen V by downregulating TGF-beta1 mRNA and protein expression. | Valsartan | transforming growth factor, beta 1 | Rattus norvegicus |