Title : Identification of the pharmacogenetic determinants of alfentanil metabolism: cytochrome P-450 3A4. An explanation of the variable elimination clearance.

Pub. Date : 1992 Sep

PMID : 1519785






1 Functional Relationships(s)
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1 It has been shown previously that alfentanil clearance is independent of the polymorphic debrisoquine hydroxylase (P-450 2D6), and it is therefore of interest to identify the human cytochrome P-450 enzymes involved in noralfentanil formation, the primary reaction involved in the oxidative N-dealkylation at the piperidine nitrogen. Alfentanil cytochrome P450 family 4 subfamily F member 3 Homo sapiens