Title : Identification of Val117 and Arg372 as critical amino acid residues for the activity difference between human CYP2A6 and CYP2A13 in coumarin 7-hydroxylation.

Pub. Date : 2004 Jul 15

PMID : 15196988






3 Functional Relationships(s)
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1 Identification of Val117 and Arg372 as critical amino acid residues for the activity difference between human CYP2A6 and CYP2A13 in coumarin 7-hydroxylation. coumarin cytochrome P450 family 2 subfamily A member 13 Homo sapiens
2 Although CYP2A13 shares a 93.5% identity with CYP2A6 in the amino acid sequence, it is only about one-tenth as active as CYP2A6 in catalyzing coumarin 7-hydroxylation. coumarin cytochrome P450 family 2 subfamily A member 13 Homo sapiens
3 Based on the crystal structure of CYP2C5, we have generated the homology models of CYP2A6 and CYP2A13 and docked the substrate coumarin to the active site. coumarin cytochrome P450 family 2 subfamily A member 13 Homo sapiens