Title : Acute treatment with the antidepressant fluoxetine internalizes 5-HT1A autoreceptors and reduces the in vivo binding of the PET radioligand [18F]MPPF in the nucleus raphe dorsalis of rat.

Pub. Date : 2004 Jun 9

PMID : 15190115






1 Functional Relationships(s)
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1 We have demonstrated previously, using immunoelectron microscopy with specific 5-HT1A antibodies, that an internalization of 5-HT1A autoreceptors is associated with their desensitization in rats given a single dose of the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin. 8-Hydroxy-2-(di-n-propylamino)tetralin 5-hydroxytryptamine receptor 1A Homo sapiens