Title : Kupffer cells and reactive oxygen species partially mediate lipopolysaccharide-induced downregulation of nuclear receptor pregnane x receptor and its target gene CYP3a in mouse liver.

Pub. Date : 2004 Jul 1

PMID : 15183191






2 Functional Relationships(s)
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1 Allopurinol and diphenyleneiodonium chloride pretreatment also attenuated the repressive effects of LPS on dexamethasone-, rifampicin-, mifepristone-, and phenobarbital-inducible CYP3A11 mRNA expression and ERND catalytic activity in mouse liver. Phenobarbital cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus
2 These antioxidants also prevented the repressive effects of LPS on dexamethasone-, rifampicin-, mifepristone-, and phenobarbital-inducible CYP3A11 mRNA expression and ERND catalytic activity in mouse liver. Phenobarbital cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus