Title : Kupffer cells and reactive oxygen species partially mediate lipopolysaccharide-induced downregulation of nuclear receptor pregnane x receptor and its target gene CYP3a in mouse liver.

Pub. Date : 2004 Jul 1

PMID : 15183191






1 Functional Relationships(s)
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1 LPS also represses the upregulation of CYP3A11 mRNA levels and erythromycin N-demethylase (ERND) catalytic activity in mice pretreated with PXR ligands dexamethasone, rifampicin, mifepristone, and phenobarbital. Rifampin nuclear receptor subfamily 1, group I, member 2 Mus musculus