Title : Disparate effects of relaxin and TGFbeta1: relaxin increases, but TGFbeta1 inhibits, the relaxin receptor and the production of IGFBP-1 in human endometrial stromal/decidual cells.

Pub. Date : 2004 Jul

PMID : 15155604






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The effect of RLX on insulin-like growth factor binding protein-1 (IGFBP-1) production was determined to evaluate the biological function of RLX/receptor in human endometrial cells. Relaxin insulin like growth factor binding protein 1 Homo sapiens
2 The effect of RLX on insulin-like growth factor binding protein-1 (IGFBP-1) production was determined to evaluate the biological function of RLX/receptor in human endometrial cells. Relaxin insulin like growth factor binding protein 1 Homo sapiens
3 In stromal cells, MPA alone caused a slight increase (2-4-fold) of the production rate of IGFBP-1 whereas MPA plus RLX synergistically increased (>40-fold) the IGFBP-1 production. Relaxin insulin like growth factor binding protein 1 Homo sapiens
4 CONCLUSION: The present study showed that in undifferentiated endometrial stromal cells, progestin increases the RLX receptor content to enhance the effect of RLX on the target gene (IGFBP-1). Relaxin insulin like growth factor binding protein 1 Homo sapiens