Title : Stereoselective synthesis of a potent thrombin inhibitor by a novel P2-P3 lactone ring opening.

Pub. Date : 2004 May 28

PMID : 15152989






2 Functional Relationships(s)
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1 The concise synthesis of a potent thrombin inhibitor was accomplished by a mild lactone aminolysis between an orthogonally protected bis-benzylic amine and a diastereomerically pure lactone. Lactones coagulation factor II, thrombin Homo sapiens
2 The concise synthesis of a potent thrombin inhibitor was accomplished by a mild lactone aminolysis between an orthogonally protected bis-benzylic amine and a diastereomerically pure lactone. Lactones coagulation factor II, thrombin Homo sapiens