Title : Neural basis for the hyperalgesic action of cholecystokinin in the rostral ventromedial medulla.

Pub. Date : 2004 Oct

PMID : 15152023






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1 We showed previously that a low dose of CCK microinjected into the rostral ventromedial medulla (RVM) blocked the analgesic effect of systemically administered morphine by preventing activation of off-cells, which are the antinociceptive output of this well characterized pain-modulating region. Morphine cholecystokinin Rattus norvegicus