Title : Transactivation of the PPAR-responsive enhancer module in chemopreventive glutathione S-transferase gene by the peroxisome proliferator-activated receptor-gamma and retinoid X receptor heterodimer.

Pub. Date : 2004 May 15

PMID : 15150131






2 Functional Relationships(s)
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1 PGJ2 + RA increased the binding of the PPARgamma - RXR heterodimer to the putative PPAR-response elements (PPREs) in the GSTA2 promoter. 9-deoxy-delta-9-prostaglandin D2 glutathione S-transferase alpha 2 Homo sapiens
2 Transactivation of PPREM by the PPARgamma - RXR heterodimer was verified by the effective GSTA2 induction in the cells treated with PGJ2 + RA after transfecting them with the plasmids encoding PPARgamma1 and RXRalpha. 9-deoxy-delta-9-prostaglandin D2 glutathione S-transferase alpha 2 Homo sapiens