Title : Catalysis and binding of cyclophilin A with different HIV-1 capsid constructs.

Pub. Date : 2004 May 25

PMID : 15147195






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The prolyl isomerase cyclophilin A (CypA) is required for efficient HIV-1 replication and is incorporated into virions through a binding interaction at the Gly-Pro(222) bond located within the capsid domain of the HIV-1 Gag precursor polyprotein (Pr(gag)). Proline peptidylprolyl isomerase A Homo sapiens
2 To address the proposal that CypA interacts with Gly-Pro sequences in the C-terminal domain of a mature capsid, the interaction between CypA and the natively folded, full-length capsid protein (CA(FL)) has been investigated here using nuclear magnetic resonance spectroscopy. Proline peptidylprolyl isomerase A Homo sapiens