Title : Sonic hedgehog signaling regulates Gli3 processing, mesenchymal proliferation, and differentiation during mouse lung organogenesis.

Pub. Date : 2004 Jun 1

PMID : 15136151






1 Functional Relationships(s)
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1 In Shh(-/-) or cyclopamine-treated wild-type (WT) lung, we found that Gli3R level is elevated, and this upregulation appears to contribute to defects in proliferation and differentiation observed in the Shh(-/-) mesenchyme, where Gli3 is normally expressed. cyclopamine GLI-Kruppel family member GLI3 Mus musculus