Title : Null phenotype for cytochrome P450 2B2 in the rat results from a deletion of its structural gene.

Pub. Date : 1992 Aug

PMID : 1513322






2 Functional Relationships(s)
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1 The absence of phenobarbital (PB)-inducible cytochrome P450 2B2 (CYP2B2) in hepatic microsomes from Marshall 520 (M520) and Wistar Munich (WM) inbred strains of rat was previously reported [Biochem. Phenobarbital cytochrome P450, family 2, subfamily b, polypeptide 2 Rattus norvegicus
2 In the present study, solution hybridization was used to quantify PB-induced CYP2B2 and CYP2B1 mRNAs in livers from M520, WM, and outbred Sprague-Dawley rats, as well as additional inbred strains that express all known electrophoretic phenotypes for both of these closely related isozymes. Phenobarbital cytochrome P450, family 2, subfamily b, polypeptide 2 Rattus norvegicus