Title : Neuregulin1 downregulates postsynaptic GABAA receptors at the hippocampal inhibitory synapse.

Pub. Date : 2004

PMID : 15132433






2 Functional Relationships(s)
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1 However, in contrast to what has been shown in other synapses, NRG1 reduces the expression of gamma-aminobutyric acid (GABA)A receptors alpha subunits in hippocampal slices, and the mean amplitude of GABAergic miniature inhibitory postsynaptic currents (IPSCs) in hippocampal CA1 pyramidal neurons, without affecting IPSC kinetics or frequency. gamma-Aminobutyric Acid neuregulin 1 Homo sapiens
2 However, in contrast to what has been shown in other synapses, NRG1 reduces the expression of gamma-aminobutyric acid (GABA)A receptors alpha subunits in hippocampal slices, and the mean amplitude of GABAergic miniature inhibitory postsynaptic currents (IPSCs) in hippocampal CA1 pyramidal neurons, without affecting IPSC kinetics or frequency. gamma-Aminobutyric Acid neuregulin 1 Homo sapiens