Title : Development of a new isogenic cell-xenograft system for evaluation of NAD(P)H:quinone oxidoreductase-directed antitumor quinones: evaluation of the activity of RH1.

Pub. Date : 2004 May 1

PMID : 15131056






2 Functional Relationships(s)
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1 PURPOSE: The purpose of our study was to develop and validate an isogenic cell line pair that differs only in the expression of NAD(P)H:quinone oxidoreductase (NQO1) that can be used to examine the in vitro and in vivo role of NQO1 in the bioactivation of the antitumor quinone RH1 (2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone), a compound currently in Phase I clinical trials. 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone NAD(P)H quinone dehydrogenase 1 Homo sapiens
2 PURPOSE: The purpose of our study was to develop and validate an isogenic cell line pair that differs only in the expression of NAD(P)H:quinone oxidoreductase (NQO1) that can be used to examine the in vitro and in vivo role of NQO1 in the bioactivation of the antitumor quinone RH1 (2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone), a compound currently in Phase I clinical trials. 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone NAD(P)H quinone dehydrogenase 1 Homo sapiens