Title : Exposure of melanoma cells to dacarbazine results in enhanced tumor growth and metastasis in vivo.

Pub. Date : 2004 Jun 1

PMID : 15123733






3 Functional Relationships(s)
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1 Previously, we have shown that short exposure of primary cutaneous melanoma cells to dacarbazine resulted in the upregulation of interleukin-8 (IL-8) and vascular endothelial growth factor (VEGF). Dacarbazine C-X-C motif chemokine ligand 8 Homo sapiens
2 Previously, we have shown that short exposure of primary cutaneous melanoma cells to dacarbazine resulted in the upregulation of interleukin-8 (IL-8) and vascular endothelial growth factor (VEGF). Dacarbazine C-X-C motif chemokine ligand 8 Homo sapiens
3 We propose that combination treatment with anti-VEGF/IL-8 or MEK inhibitors may potentiate the therapeutic effects of dacarbazine. Dacarbazine C-X-C motif chemokine ligand 8 Homo sapiens