Title : DNA binding and antigene activity of a daunomycin-conjugated triplex-forming oligonucleotide targeting the P2 promoter of the human c-myc gene.

Pub. Date : 2004

PMID : 15121897






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 The 11mer daunomycin-conjugated GT (dauno-GT11) TFO targeted a sequence upstream of the P2 promoter, a site known to be critical for transcription of the c-myc gene. tfo MYC proto-oncogene, bHLH transcription factor Homo sapiens
2 The daunomycin-conjugated TFO inhibited transcription in vitro and reduced c-myc promoter activity in prostate and breast cancer cells. tfo MYC proto-oncogene, bHLH transcription factor Homo sapiens