Title : Sustained delivery of vascular endothelial growth factor with alginate beads.

Pub. Date : 2004 May 18

PMID : 15120902






8 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Sustained delivery of vascular endothelial growth factor with alginate beads. Alginates vascular endothelial growth factor A Homo sapiens
2 In this study, VEGF was encapsulated in calcium alginate beads by the extrusion/external gelation method, and was subsequently released in PBS and in serum media. Alginates vascular endothelial growth factor A Homo sapiens
3 The objective was to optimize VEGF encapsulation yield and obtain VEGF release at a constant rate from alginate matrices in vitro. Alginates vascular endothelial growth factor A Homo sapiens
4 The rate of VEGF release from alginate beads was higher in serum than in PBS, which was due to the capacity of the serum in reducing the electrostatic interaction between alginate and VEGF. Alginates vascular endothelial growth factor A Homo sapiens
5 The rate of VEGF release from alginate beads was higher in serum than in PBS, which was due to the capacity of the serum in reducing the electrostatic interaction between alginate and VEGF. Alginates vascular endothelial growth factor A Homo sapiens
6 The rate of VEGF release from alginate beads was higher in serum than in PBS, which was due to the capacity of the serum in reducing the electrostatic interaction between alginate and VEGF. Alginates vascular endothelial growth factor A Homo sapiens
7 The presence of CaCl(2) in the release supernatant can shield the alginate interaction with VEGF, and a constant release rate of 6 ng/ml/day may be sustained for 14 days. Alginates vascular endothelial growth factor A Homo sapiens
8 These results suggest that the alginate-VEGF delivery system may be useful in the development of vascular tissue engineering and wound healing applications. Alginates vascular endothelial growth factor A Homo sapiens