Pub. Date : 2004 May
PMID : 15111505
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Insulin treatment significantly increased intracellular superoxide anion (O(2)(-)) production, an effect completely abolished by Tiron, a cell-permeable superoxide dismutase (SOD) mimetic and by polyethylene glycol (PEG)-SOD, but not by PEG catalase. | Superoxides | insulin | Homo sapiens |
| 2 | Furthermore, insulin-induced O(2)(-) production was attenuated by the NAD(P)H inhibitor apocynin, but not by rotenone or oxypurinol. | Superoxides | insulin | Homo sapiens |
| 3 | Inhibition of the phosphatidylinositol 3"-kinase (PI 3"-kinase) pathway with LY294002 blocked insulin-stimulated O(2)(-) production, suggesting a direct involvement of PI 3"-kinase in the activation of NAD(P)H oxidase. | Superoxides | insulin | Homo sapiens |
| 4 | In conclusion, these findings provided direct evidence that elevated insulin levels generate O(2)(-) by an NAD(P)H-dependent mechanism that involves the activation of PI 3"-kinase and stimulates ERK-1- and ERK-2-dependent pathways. | Superoxides | insulin | Homo sapiens |