Title : Insulin generates free radicals by an NAD(P)H, phosphatidylinositol 3'-kinase-dependent mechanism in human skin fibroblasts ex vivo.

Pub. Date : 2004 May

PMID : 15111505






1 Functional Relationships(s)
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1 In conclusion, these findings provided direct evidence that elevated insulin levels generate O(2)(-) by an NAD(P)H-dependent mechanism that involves the activation of PI 3"-kinase and stimulates ERK-1- and ERK-2-dependent pathways. Superoxides mitogen-activated protein kinase 3 Homo sapiens