Title : Pro-Th1 cytokines promote Fas-dependent apoptosis of immature peripheral basophils.

Pub. Date : 2004 May 1

PMID : 15100264






2 Functional Relationships(s)
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1 We have previously characterized immature hemopoietic cells of the basophil lineage as a lin(-)c-kit(-) population, which responds to IL-3 by enhancing its histamine synthesis through histidine decarboxylase activation. Histamine interleukin 3 Mus musculus
2 2) Fas or Fas ligand deficiency in mutant mice abolished the inhibitory effect of IL-12 plus IL-18 on IL-3-induced histamine production. Histamine interleukin 3 Mus musculus