Title : Competitive and open channel block of recombinant nAChR channels by different antibiotics.

Pub. Date : 2004 May

PMID : 15099589






2 Functional Relationships(s)
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1 Using a modified patch-clamp technique in combination with an ultrafast system for solution exchange we investigated the functional interaction of gentamicin, penicillin G, tetracycline, erythromycin and ceftriaxone with nAChR transiently transfected into HEK293 cells as a potential molecular target. Tetracycline cholinergic receptor nicotinic alpha 4 subunit Homo sapiens
2 Gentamicin, penicillin G, tetracycline and erythromycin induced a combination of open channel and competitive block of nAChR channel currents whereas ceftriaxone had no effect. Tetracycline cholinergic receptor nicotinic alpha 4 subunit Homo sapiens