Title : Conventional protein kinase C and atypical protein kinase Czeta differentially regulate macrophage production of tumour necrosis factor-alpha and interleukin-10.

Pub. Date : 2004 May

PMID : 15096183






4 Functional Relationships(s)
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1 In this report, we have investigated the involvement of PKC and cAMP in the production of TNF-alpha and IL-10 by peripheral blood monocyte-derived macrophages. Cyclic AMP interleukin 10 Homo sapiens
2 Cyclic-AMP augmented IL-10 production and cAMP response element binding protein activation upon stimulation by PMA/ionomycin. Cyclic AMP interleukin 10 Homo sapiens
3 In addition, cAMP activated PKCzeta; inhibition of which, by a dominant negative adenovirus construct, selectively suppressed IL-10 production. Cyclic AMP interleukin 10 Homo sapiens
4 These observations suggest that pro-inflammatory and anti-inflammatory cytokines are differentially regulated by PKC isoforms; TNF-alpha being dependent on conventional PKCs (alpha and beta) whereas IL-10 is regulated by the cAMP-regulated atypical PKCzeta. Cyclic AMP interleukin 10 Homo sapiens