Title : Anti-apoptotic effects of curcumin on photosensitized human epidermal carcinoma A431 cells.

Pub. Date : 2004 May 1

PMID : 15095415






2 Functional Relationships(s)
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1 We report that curcumin prevented PDT-induced JNK activation, mitochondrial release of cytochrome c, caspase-3 activation, and cleavage of PAK2. Curcumin mitogen-activated protein kinase 8 Homo sapiens
2 Collectively, these results demonstrate that singlet oxygen triggers JNK activation, cytochrome c release, caspase activation and subsequent apoptotic biochemical changes during PDT and show that curcumin is a potent inhibitor for this process. Curcumin mitogen-activated protein kinase 8 Homo sapiens