Title : The effect of quinidine, used as a probe for the involvement of P-glycoprotein, on the intestinal absorption and pharmacodynamics of methadone.

Pub. Date : 2004 May

PMID : 15089813






1 Functional Relationships(s)
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1 CONCLUSIONS: Quinidine increased the plasma concentrations of oral methadone in the absorptive phase and the miosis caused by methadone, suggesting that intestinal P-gp affects oral methadone absorption and hence its clinical effects. Quinidine ATP binding cassette subfamily B member 1 Homo sapiens