Title : Leu-574 of human HIF-1alpha is a molecular determinant of prolyl hydroxylation.

Pub. Date : 2004 Jun

PMID : 15084514






2 Functional Relationships(s)
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1 Recently, we demonstrated that Leu-574 of human HIF-1alpha--10 residues downstream of Pro-564--is essential for VHL recognition. Proline hypoxia inducible factor 1 subunit alpha Homo sapiens
2 An antibody specific for hydroxylated Pro-564 has been used to determine the hydroxylation status; mutation or deletion of Leu-574 results in a significant decrease in the ratio of the hydroxylated HIF-1alpha to the total amount. Proline hypoxia inducible factor 1 subunit alpha Homo sapiens