Title : Pharmacogenetic determinants of interindividual variability in bupropion hydroxylation by cytochrome P450 2B6 in human liver microsomes.

Pub. Date : 2004 Apr

PMID : 15083067






2 Functional Relationships(s)
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1 A consideration of the effects of these variables on CYP2B6 mRNA and protein levels suggests that alcohol use is associated with enhanced CYP2B6 gene transcription, but the presence of at least one *6B allele reduces this effect on bupropion hydroxylation at the post-transcriptional level. Alcohols cytochrome P450 family 2 subfamily B member 6 Homo sapiens
2 A consideration of the effects of these variables on CYP2B6 mRNA and protein levels suggests that alcohol use is associated with enhanced CYP2B6 gene transcription, but the presence of at least one *6B allele reduces this effect on bupropion hydroxylation at the post-transcriptional level. Alcohols cytochrome P450 family 2 subfamily B member 6 Homo sapiens