Title : Protein kinase C-mediated phosphorylation of the leukemia-associated HOXA9 protein impairs its DNA binding ability and induces myeloid differentiation.

Pub. Date : 2004 May

PMID : 15082777






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 This phosphorylation was enhanced by phorbol ester, a known inducer of PKC, and was inhibited by a specific PKC inhibitor. Phorbol Esters proline rich transmembrane protein 2 Homo sapiens
2 This phosphorylation was enhanced by phorbol ester, a known inducer of PKC, and was inhibited by a specific PKC inhibitor. Phorbol Esters proline rich transmembrane protein 2 Homo sapiens
3 PKC inhibition significantly reduced the phorbol-ester induced differentiation of the PLB985 hematopoietic cell line as well as HOXA9-immortalized murine bone marrow cells. Phorbol Esters proline rich transmembrane protein 2 Homo sapiens
4 These data suggest that phorbol ester-induced myeloid differentiation is in part due to PKC-mediated phosphorylation of HOXA9, which decreases the DNA binding of the homeoprotein. Phorbol Esters proline rich transmembrane protein 2 Homo sapiens