Pub. Date : 2004 Sep
PMID : 15082752
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The present study documents a role for brain-derived tumor necrosis factor-alpha (TNF) in the mechanism of action of the antidepressant drug desmethylimipramine (desipramine). | Desipramine | tumor necrosis factor | Rattus norvegicus |
| 2 | The present study documents a role for brain-derived tumor necrosis factor-alpha (TNF) in the mechanism of action of the antidepressant drug desmethylimipramine (desipramine). | Desipramine | tumor necrosis factor | Rattus norvegicus |
| 3 | Chronic desipramine administration transforms TNF-mediated inhibition of NE release to facilitation, dependent upon alpha2-adrenergic receptor activation. | Desipramine | tumor necrosis factor | Rattus norvegicus |
| 4 | To determine whether this transformation is due to desipramine-induced inhibition of TNF bioactivity in the brain, rats were i.c.v. | Desipramine | tumor necrosis factor | Rattus norvegicus |
| 5 | Although simultaneous microinfusion of rrTNF with chronic desipramine administration prevents the transformation induced by desipramine, microinfusion of rrTNF enhances TNF inhibition of NE release. | Desipramine | tumor necrosis factor | Rattus norvegicus |
| 6 | microinfusion of rrTNF with concomitant desipramine administration opposes decreases in neuron-associated TNF levels, required to transform presynaptic sensitivity to TNF, which is necessary for the drug to be efficacious. | Desipramine | tumor necrosis factor | Rattus norvegicus |