Title : Platelet-derived growth factor stimulation of GTPase-activating protein tyrosine phosphorylation in control and c-H-ras-expressing NIH 3T3 cells correlates with p21ras activation.

Pub. Date : 1992 Sep

PMID : 1508192






4 Functional Relationships(s)
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1 Furthermore, PDGF exposure led to a rapid and sustained increase in the levels of p21ras bound to GTP, with kinetics similar to those observed for GAP tyrosine phosphorylation. Guanosine Triphosphate Harvey rat sarcoma virus oncogene Mus musculus
2 The PDGF-induced increases in GTP-bound p21ras in NIH 3T3 cells were comparable to the steady-state level observed in serum-starved c-H-ras-overexpressing transformants, conditions in which these cells maintained high rates of DNA synthesis. Guanosine Triphosphate Harvey rat sarcoma virus oncogene Mus musculus
3 Addition of PDGF to c-H-ras-overexpressing cells also resulted in a rapid and sustained increase in GTP-bound p21ras. Guanosine Triphosphate Harvey rat sarcoma virus oncogene Mus musculus
4 Addition of PDGF to c-H-ras-overexpressing cells also resulted in a rapid and sustained increase in GTP-bound p21ras. Guanosine Triphosphate Harvey rat sarcoma virus oncogene Mus musculus