Title : MK-801 prevents the increased NMDA-NR1 and NR2B subunits mRNA expression observed in the hippocampus of rats tolerant to diazepam.

Pub. Date : 2004 May 15

PMID : 15081382






1 Functional Relationships(s)
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1 Our results demonstrate that the development of tolerance to the hypolocomotive effect of diazepam, along with the increased hippocampal synaptic plasticity and the associated over expression of the mRNA NR1 and NR2B N-methyl-D-aspartate receptor subunits, were blocked by previous MK-801 administration. Diazepam glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus