Pub. Date : 2004 Mar-Apr
PMID : 15072464
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we investigated the molecular mechanisms of the resistance to Fas-mediated apoptosis and sensitization to Fas-induced cell death by IFN-gamma in human astrocytoma cells. | ammonium ferrous sulfate | interferon gamma | Homo sapiens |
| 2 | Interestingly, caspase-1 protein expression but not that of caspase-3 nor -8 was up-regulated by IFN-gamma only in Fas-sensitive CRT-J cells but not in Fas-resistant U373-MG cells. | ammonium ferrous sulfate | interferon gamma | Homo sapiens |
| 3 | These results collectively suggest that caspase-1, along with caspases-3 and -8, mediate Fas-induced cell death in human astrocytoma cells, and post-transcriptional regulation of caspase-1 may determine the responsiveness to IFN-gamma-induced sensitization to Fas-mediated apoptosis. | ammonium ferrous sulfate | interferon gamma | Homo sapiens |