Pub. Date : 2004
PMID : 15069761
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Action of troxacitabine on cells transduced with human cytidine deaminase cDNA. | troxacitabine | cytidine deaminase | Homo sapiens |
| 2 | In contrast to other cytosine nucleoside analogs, troxacitabine is resistant to inactivation by cytidine deaminase (CD). | troxacitabine | cytidine deaminase | Homo sapiens |
| 3 | In contrast to other cytosine nucleoside analogs, troxacitabine is resistant to inactivation by cytidine deaminase (CD). | troxacitabine | cytidine deaminase | Homo sapiens |
| 4 | In this study we have investigated the effects of increased intracellular levels of CD on the antineoplastic action of troxacitabine and the related antileukemic drug, cytosine arabinoside (ARA-C). | troxacitabine | cytidine deaminase | Homo sapiens |
| 5 | In contrast, the CD-transduced cells were as or more sensitive to the cytotoxic action of troxacitabine than the wild type cells. | troxacitabine | cytidine deaminase | Homo sapiens |
| 6 | These results suggest that troxacitabine may be an effective antineoplastic agent against tumors with high levels of CD that show drug resistance to cytosine nucleoside analogs. | troxacitabine | cytidine deaminase | Homo sapiens |