Pub. Date : 2004 Jun 4
PMID : 15069084
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Mitogen-induced rapid phosphorylation of serine 795 of the retinoblastoma gene product in vascular smooth muscle cells involves ERK activation. | Serine | mitogen-activated protein kinase 1 | Homo sapiens |
2 | Rb Ser(795) phosphorylation could be blocked by PD98059, a MEK inhibitor, and greatly attenuated by apigenin, an inhibitor of the Ras --> Raf --> MEK --> ERK pathway. | Serine | mitogen-activated protein kinase 1 | Homo sapiens |
3 | These studies show a rapid, novel, and selective phosphorylation of Rb Ser(795) by mitogens and demonstrate an unexpected rapid linkage between the actions of the Ras --> Raf --> MEK --> ERK pathway and the phosphorylation state of Rb. | Serine | mitogen-activated protein kinase 1 | Homo sapiens |