Title : Mitogen-induced rapid phosphorylation of serine 795 of the retinoblastoma gene product in vascular smooth muscle cells involves ERK activation.

Pub. Date : 2004 Jun 4

PMID : 15069084






3 Functional Relationships(s)
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1 Mitogen-induced rapid phosphorylation of serine 795 of the retinoblastoma gene product in vascular smooth muscle cells involves ERK activation. Serine mitogen-activated protein kinase 1 Homo sapiens
2 Rb Ser(795) phosphorylation could be blocked by PD98059, a MEK inhibitor, and greatly attenuated by apigenin, an inhibitor of the Ras --> Raf --> MEK --> ERK pathway. Serine mitogen-activated protein kinase 1 Homo sapiens
3 These studies show a rapid, novel, and selective phosphorylation of Rb Ser(795) by mitogens and demonstrate an unexpected rapid linkage between the actions of the Ras --> Raf --> MEK --> ERK pathway and the phosphorylation state of Rb. Serine mitogen-activated protein kinase 1 Homo sapiens