Pub. Date : 2004
PMID : 15067207
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Neonatal capsaicin treatment affects rat thymocyte proliferation and cell death by modulating substance P and neurokinin-1 receptor expression. | Capsaicin | tachykinin receptor 1 | Rattus norvegicus |
| 2 | Herein we provide evidence that substance P (SP) and its neurokinin-1 receptor (NK-1R) expressed on thymocytes counteract thymus depletion induced by neonatal capsaicin (CPS) treatment by affecting thymocyte proliferation and apoptotic death. | Capsaicin | tachykinin receptor 1 | Rattus norvegicus |
| 3 | Herein we provide evidence that substance P (SP) and its neurokinin-1 receptor (NK-1R) expressed on thymocytes counteract thymus depletion induced by neonatal capsaicin (CPS) treatment by affecting thymocyte proliferation and apoptotic death. | Capsaicin | tachykinin receptor 1 | Rattus norvegicus |
| 4 | Herein we provide evidence that substance P (SP) and its neurokinin-1 receptor (NK-1R) expressed on thymocytes counteract thymus depletion induced by neonatal capsaicin (CPS) treatment by affecting thymocyte proliferation and apoptotic death. | Capsaicin | tachykinin receptor 1 | Rattus norvegicus |
| 5 | Herein we provide evidence that substance P (SP) and its neurokinin-1 receptor (NK-1R) expressed on thymocytes counteract thymus depletion induced by neonatal capsaicin (CPS) treatment by affecting thymocyte proliferation and apoptotic death. | Capsaicin | tachykinin receptor 1 | Rattus norvegicus |
| 6 | SP administration reversed the CPS-mediated inhibitory effects on the total thymocyte number and subset distribution, namely CD4+ and CD4- CD8- cells, through its interaction with NK-1R as shown by concomitant NK-1R (SR140333) antagonist administration. | Capsaicin | tachykinin receptor 1 | Rattus norvegicus |
| 7 | SP administration reversed the CPS-mediated inhibitory effects on the total thymocyte number and subset distribution, namely CD4+ and CD4- CD8- cells, through its interaction with NK-1R as shown by concomitant NK-1R (SR140333) antagonist administration. | Capsaicin | tachykinin receptor 1 | Rattus norvegicus |
| 8 | By contrast, NK-1R mRNA levels were increased in thymocytes from CPS-treated rats. | Capsaicin | tachykinin receptor 1 | Rattus norvegicus |
| 9 | Exogenous SP administration augmented PPT-A, SP and NK-1R thymocyte expression in CPS-treated rats, and this enhancement was antagonized by SR140333 administration. | Capsaicin | tachykinin receptor 1 | Rattus norvegicus |
| 10 | Overall, our results strongly suggest that the immunomodulatory effects of neonatal CPS treatment on rat thymocyte functions are dependent on vanilloid-mediated regulation of SP and NK-1R functional expression by neuronal and immune cells. | Capsaicin | tachykinin receptor 1 | Rattus norvegicus |
| 11 | Overall, our results strongly suggest that the immunomodulatory effects of neonatal CPS treatment on rat thymocyte functions are dependent on vanilloid-mediated regulation of SP and NK-1R functional expression by neuronal and immune cells. | Capsaicin | tachykinin receptor 1 | Rattus norvegicus |