Title : Dominant-negative c-Jun (TAM67) target genes: HMGA1 is required for tumor promoter-induced transformation.

Pub. Date : 2004 May 27

PMID : 15064752






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 One of the identified genes, the high-mobility group protein A1 (Hmga1) is induced by TPA in P+, but not in transformation-resistant P cells. Tetradecanoylphorbol Acetate high mobility group AT-hook 1 Homo sapiens
2 One of the identified genes, the high-mobility group protein A1 (Hmga1) is induced by TPA in P+, but not in transformation-resistant P cells. Tetradecanoylphorbol Acetate high mobility group AT-hook 1 Homo sapiens
3 We show that TPA induction of the architectural transcription factor HMGA1 is inhibited by TAM67, is extracellular-signal-regulated kinase (ERK)-activation dependent, and is mediated by AP-1. Tetradecanoylphorbol Acetate high mobility group AT-hook 1 Homo sapiens
4 HMGA1 antisense construct transfected into P+ cells blocked HMGA1 protein expression and inhibited TPA-induced transformation indicating that HMGA1 is required for transformation. Tetradecanoylphorbol Acetate high mobility group AT-hook 1 Homo sapiens