Pub. Date : 1992 Sep
PMID : 1506412
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | However, we now report that TPA-treated and non-treated SH-SY5Y cells express PKC-alpha, but not PKC-beta and PKC-gamma, mRNA. | Tetradecanoylphorbol Acetate | protein kinase C alpha | Homo sapiens |
| 2 | Furthermore, only a slight down-regulation of the PKC-alpha protein could be seen during prolonged treatment with 16 nM TPA, the concentration giving optimal differentiation. | Tetradecanoylphorbol Acetate | protein kinase C alpha | Homo sapiens |
| 3 | In contrast, a higher concentration of TPA (1.6 microM) results in a poor neuronal differentiation and a complete down-regulation of PKC-alpha. | Tetradecanoylphorbol Acetate | protein kinase C alpha | Homo sapiens |
| 4 | PKC-alpha was rapidly translocated to the particulate fraction and remained membrane bound for at least 4 days during treatment with 16 nM TPA. | Tetradecanoylphorbol Acetate | protein kinase C alpha | Homo sapiens |