Pub. Date : 2004 Apr 1
PMID : 15059889
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Stat1, Stat3, and Stat5 were activated in mouse epidermis after treatment with different classes of tumor promoters, including 12-O-tetradecanoylphorbol-13-acetate (TPA), okadaic acid, and chrysarobin. | Tetradecanoylphorbol Acetate | signal transducer and activator of transcription 3 | Mus musculus |
| 2 | In addition, Stat1, Stat3, and Stat5 were constitutively activated in skin tumors generated by the two-stage carcinogenesis regimen using 7,12-dimethylbenz(a)anthracene as initiator and TPA as promoter. | Tetradecanoylphorbol Acetate | signal transducer and activator of transcription 3 | Mus musculus |
| 3 | Abrogation of EGFR function in mouse epidermis using an EGFR kinase inhibitor or by overexpressing a dominant negative form of EGFR led to a reduction in Stat3 activation in response to TPA treatment. | Tetradecanoylphorbol Acetate | signal transducer and activator of transcription 3 | Mus musculus |
| 4 | Immunoprecipitation analyses using lysates from TPA-treated epidermis and skin papillomas showed enhanced interaction between the EGFR and Stat3. | Tetradecanoylphorbol Acetate | signal transducer and activator of transcription 3 | Mus musculus |
| 5 | Finally, Stat3 deficiency in mouse epidermis significantly reduced the proliferative response after TPA treatment. | Tetradecanoylphorbol Acetate | signal transducer and activator of transcription 3 | Mus musculus |