Title : Cocaine-induced intracellular signaling and gene expression are oppositely regulated by the dopamine D1 and D3 receptors.

Pub. Date : 2004 Mar 31

PMID : 15056714






4 Functional Relationships(s)
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1 We show that extracellular signal-regulated kinase (ERK) activation and c-fos induction in the CPu in response to acute cocaine administration is mediated by the D1 receptor and inhibited by the D3 receptor. Cocaine FBJ osteosarcoma oncogene Mus musculus
2 Moreover, ERK activation mediates acute cocaine-induced expression of Fos family genes, including c-fos, fosB and fra2. Cocaine FBJ osteosarcoma oncogene Mus musculus
3 Moreover, ERK activation mediates acute cocaine-induced expression of Fos family genes, including c-fos, fosB and fra2. Cocaine FBJ osteosarcoma oncogene Mus musculus
4 These results suggest that the D1 and D3 receptors elicit opposite regulation of target gene expression by regulating ERK activation and c-fos induction after acute and chronic cocaine treatment. Cocaine FBJ osteosarcoma oncogene Mus musculus