Title : Interferon alpha-induced apoptosis in tumor cells is mediated through the phosphoinositide 3-kinase/mammalian target of rapamycin signaling pathway.

Pub. Date : 2004 Jun 4

PMID : 15056668






2 Functional Relationships(s)
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1 Pharmacological inhibition of PI3K activity by Ly294002 disrupted IFN-induced apoptosis upstream of mitochondria. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one interferon alpha 1 Homo sapiens
2 A PI3K and mTOR-dependent phosphorylation of p70S6 kinase and 4E-BP1 repressor was induced by IFNalpha treatment of cells and was strongly inhibited by Ly294002 or rapamycin. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one interferon alpha 1 Homo sapiens