Title : The metabolism of the piperazine-type phenothiazine neuroleptic perazine by the human cytochrome P-450 isoenzymes.

Pub. Date : 2004 May

PMID : 15056479






1 Functional Relationships(s)
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1 alpha-Naphthoflavone (a CYP1A2 inhibitor) and ketoconazole (a CYP3A4 inhibitor) significantly decreased the rate of perazine 5-sulphoxidation, while ticlopidine (a CYP2C19 inhibitor) strongly reduced the rate of perazine N-demethylation in human liver microsomes. Ticlopidine cytochrome P450 family 2 subfamily C member 19 Homo sapiens