Title : Synthesis and biological evaluation of 2,3-diarylpyrazines and quinoxalines as selective COX-2 inhibitors.

Pub. Date : 2004 Apr 15

PMID : 15051057






1 Functional Relationships(s)
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1 Several 2,3-diaryl pyrazines and quinoxalines with 4-sulfamoyl (SO(2)NH(2))/methylsulfonyl (SO(2)Me)-phenyl pharmacophores have been synthesized and evaluated for the cyclooxygenase (COX-1/COX-2) inhibitory activity. methylsulfonyl mitochondrially encoded cytochrome c oxidase II Homo sapiens