Title : Improved energy coupling of human P-glycoprotein by the glycine 185 to valine mutation.

Pub. Date : 2004 Apr 6

PMID : 15049699






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The high transition state energies of wild-type P-glycoprotein, when transporting etoposide or colchicine, increase the probability of nonproductive degradation of the transition state without transport. Etoposide ATP binding cassette subfamily B member 1 Homo sapiens
2 G185V P-glycoprotein transports etoposide or colchicine in an energetically more efficient way with decreased enthalpic and entropic components of the activation energy. Etoposide ATP binding cassette subfamily B member 1 Homo sapiens