Title : Chk2 drives late G1/early S phase arrest of clonal myeloid progenitors expressing the p210 BCR-ABL tyrosine kinase in response to STI571.

Pub. Date : 2004

PMID : 15048068






1 Functional Relationships(s)
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1 Here, we demonstrated that STI571 also induces growth arrest by activating the Chk2-Cdc25A-Cdk2 axis, a pathway complementary to p53 in the activation of G(1)/S cell cycle checkpoint. Imatinib Mesylate tumor protein p53 Homo sapiens