Pub. Date : 2004 Mar 15
PMID : 15041737
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Characterization of p53 wild-type and null isogenic colorectal cancer cell lines resistant to 5-fluorouracil, oxaliplatin, and irinotecan. | Oxaliplatin | tumor protein p53 | Homo sapiens |
| 2 | In addition, we found that resistance to 5-FU and oxaliplatin was higher in parental p53(-/-) cells compared with parental p53(+/+) cells, with an approximately 5-fold increase in IC(50 (72 h)) for each drug. | Oxaliplatin | tumor protein p53 | Homo sapiens |
| 3 | In addition, we found that resistance to 5-FU and oxaliplatin was higher in parental p53(-/-) cells compared with parental p53(+/+) cells, with an approximately 5-fold increase in IC(50 (72 h)) for each drug. | Oxaliplatin | tumor protein p53 | Homo sapiens |
| 4 | Furthermore, apoptosis after treatment with 5-FU and oxaliplatin, but not CPT-11, was significantly reduced in parental p53(-/-) cells compared with parental p53(+/+) cells. | Oxaliplatin | tumor protein p53 | Homo sapiens |
| 5 | Furthermore, apoptosis after treatment with 5-FU and oxaliplatin, but not CPT-11, was significantly reduced in parental p53(-/-) cells compared with parental p53(+/+) cells. | Oxaliplatin | tumor protein p53 | Homo sapiens |
| 6 | These data suggest that p53 may be an important determinant of sensitivity to 5-FU and oxaliplatin but not CPT-11. | Oxaliplatin | tumor protein p53 | Homo sapiens |