Title : Differences in substrate and inhibitor sequence specificity of human, mouse and rat tissue kallikreins.

Pub. Date : 2004 Jun 15

PMID : 15040788






6 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Bradykinin was released from these peptides by the mK1- and rK1-mediated hydrolysis of Arg-Arg and Arg-Ser (or Arg-Ala) peptide bonds. Arginine kininogen 1 Homo sapiens
2 Bradykinin was released from these peptides by the mK1- and rK1-mediated hydrolysis of Arg-Arg and Arg-Ser (or Arg-Ala) peptide bonds. Arginine kininogen 1 Homo sapiens
3 Bradykinin was released from these peptides by the mK1- and rK1-mediated hydrolysis of Arg-Arg and Arg-Ser (or Arg-Ala) peptide bonds. Arginine kininogen 1 Homo sapiens
4 Bradykinin was released from these peptides by the mK1- and rK1-mediated hydrolysis of Arg-Arg and Arg-Ser (or Arg-Ala) peptide bonds. Arginine kininogen 1 Homo sapiens
5 One of these peptides, Abz-GFSPFRAPRVQ-EDDnp (where EDDnp stands for ethylenediamine 2,4-dinitrophenyl), was preferentially hydrolysed at the Phe-Arg bond, confirming the potential des-[Arg9]bradykinin-releasing activity of hK1 on rat kininogen. Arginine kininogen 1 Homo sapiens
6 The proline residue that is two residues upstream of bradykinin in rat kininogen is, in part, responsible for this pattern of hydrolysis, since the peptide Abz-GFSPFRASRVQ-EDDnp was preferentially cleaved at the Arg-Ala bond by hK1. Arginine kininogen 1 Homo sapiens