Title : Glutathione propagates oxidative stress triggered by myeloperoxidase in HL-60 cells. Evidence for glutathionyl radical-induced peroxidation of phospholipids and cytotoxicity.

Pub. Date : 2004 May 28

PMID : 15039448






3 Functional Relationships(s)
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Protein Name
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1 Glutathione propagates oxidative stress triggered by myeloperoxidase in HL-60 cells. Glutathione myeloperoxidase Homo sapiens
2 Horseradish peroxidase-, myeloperoxidase-, and cyclooxygenasecatalyzed oxidation of phenol in the presence of H2O2 and GSH caused the generation of phenoxyl radicals and GS* radicals, of which only the latter reacted with Ac-Tempo. Glutathione myeloperoxidase Homo sapiens
3 Thus, GSH, commonly viewed as a universal free radical scavenger and major intracellular antioxidant, acts as a pro-oxidant during myeloperoxidase-catalyzed metabolism of phenol in HL-60 cells. Glutathione myeloperoxidase Homo sapiens