Title : Key structural features of ligands for activation of human pregnane X receptor.

Pub. Date : 2004 Apr

PMID : 15039302






1 Functional Relationships(s)
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1 In the case of hydantoins, only mephenytoin and ethotoin, which have an alkylchain at the R1-position, strongly activated hPXR at 300 microM. Mephenytoin nuclear receptor subfamily 1 group I member 2 Homo sapiens